188博金宝

顾佳黎

发布者:模板发布时间:2017-06-20浏览次数:2381

一、个人简介

顾佳黎,女,19865月,浙江湖州,工学博士,讲师

二、主讲课程

有机化学、化工原理

三、学术研究方向

四、科研项目(截止20161231日,用文字描述)

主持省部级项目1项,主持市厅级项目2项,主持校级项目1项。

例:项目人员,项目名称,级别,起始时间,经费,是否结题;

1. 顾佳黎、张荣飞、王永亚、赵建华、李爱朋、杨小红,扁桃酸消旋酶热稳定性分子机制的研究及其分子改造,省部级,2016/01-2018/125万元,在研

2. 顾佳黎、李永进、赵建华、杨小红、王莎、曹访、潘国祥,氯吡格雷酶法制备工艺中扁桃酸消旋酶稳定性改造及稳定性机制研究,市厅级,2016/01-2017/122万元,在研,主持

3. 顾佳黎、赵建华、张荣飞、王永亚、潘国祥、徐敏虹,氯吡格雷酶法制备工艺中扁桃酸消旋酶的稳定性改造,市厅级,2015/10-2017/101万元,在研,主持

 

五、论文著作和专利(截止20161231日,具有代表性,填写不超过10篇)

[1] Jiali Gu, Hongfei Tong, Dongqiang Lin*, Evaluation of magnetic particles modified with a hydrophobic charge-induction ligand for antibody capture, Journal of Chromatography A, 2016, 1460: 61-67.

[2] Jiali Gu, Hongfei Tong, Lidan Ye, Hongwei Yu*, The role of aromatic residue W20 in the activity and enantioselectivity control of esterase BioH towards aryl substrate, Biochemical Engineering Journal, 2015, 101: 134-141.

[3] Jiali Gu, Lidan Ye, Fei Guo, Xiaomei Lv, Wenqiang Lu, Hongwei Yu*, Improved apparent enantioselectivity of a hydrolase by sequential hydrolysis and racemization, Tetrahedron Letters, 2015, 56(12): 1489-1491.

[4] Jiali Gu, Lidan Ye, Fei Guo, Xiaomei Lv, Wenqiang Lu, Hongwei Yu*, Rational design of esterase BioH with enhanced enantioselectivity towards methyl (S)-o-chloromandelate, Applied Microbiology and Biotechnology, 2015, 99(4): 1709-1718.

[5] Jiali Gu, Min Liu, Fei Guo, Wenping Xie, Wenqiang Lu, Lidan Ye, Zhirong Chen, Shenfeng Yuan, Hongwei Yu*, Virtual screening of mandelate racemase mutants with enhanced activity based on binding energy in the transition state, Enzyme and Microbial Technology, 2014, 55: 121-127.

[6] Jiali Gu, Hongwei Yu*, The role of residue S139 of mandelate racemase: Synergistic effect of S139 and E317 on transition state stabilization, Journal of Biomolecular Structure and Dynamics, 2012, 30(5): 585-593.

[7] Jiali Gu, Ji Liu, Hongwei Yu *, Quantitative prediction of enantioselectivity ofCandida antarctica lipase B by combining docking simulations and quantitative structure-activity relationship (QSAR) analysis, Journal of Molecular Catalysis B: Enzymatic, 2011(72): 238-247.



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